Compositions and methods for phagocyte delivery of anti-staphylococcal agents

US9644023B2 · kind B2 · utility

Assignees

• NEW YORK UNIVERSITY · US
• JANSSEN BIOTECH, INC. · US

Inventors

• Victor J. Torres · New York, US
• Randall Brezski · Spring House, US
• Anthony Lynch · Spring House, US
• William Strohl · Bound Brook, US
• Brian Whitaker · Krugerville, US
• Mark Chiu · Paoli, US
• Peter T. BUCKLEY · Spring House, US
• Keri Dorn · Spring House, US
• Michelle Kinder · Spring House, US

Key dates

• Filing date: Dec 9, 2014
• Grant date: May 9, 2017
• Expiry date: Dec 9, 2034

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2469/10
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present application generally relates to multi-specific molecules that bind to multiple bacterial virulence factors, methods for producing these binding molecules, and the use of these binding molecules to treat bacterial infections. In particular, the binding molecules comprise at least two binding domains, preferably an antibody or antibody fragment and an alternative scaffold. The first binding domain is capable of binding to a glycosylated staphylococcal surface protein, preferably an SDR-containing protein. The second binding domain is capable of binding to a staphylococcal leukotoxin, preferably LukAB, LukD or LukE. These multi-specific binding compounds have killing activity against staphylococci and, thus, can be used in the treatment and/or amelioration of a Staphylococcus infection, including methicillin-resistant Staphylococcus aureus.