Patent · US Active

Plasminogen and plasmin variants

US9644196B2 · kind B2 · utility

0Cited by

41References

45Claims

0Family size

Assignee

ThromboGenics NV · BE

Inventor

Richard Zwaal · Gent, BE

Key dates

Filing date	Aug 13, 2012
Grant date	May 9, 2017
Priority date	—
Expiry date	May 2, 2033

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to variants of plasminogen and plasmin comprising one or more point mutations in the catalytic domain which reduce or prevent autocatalytic destruction of the protease activity of plasmin. Compositions, uses and methods of using said variants of plasminogen and plasmin are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.