Dual delivery system for heterologous antigens
US9644212B2 · kind B2 · utility
10Cited by
69References
10Claims
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Key dates
| Filing date | Mar 11, 2014 |
| Grant date | May 9, 2017 |
| Priority date | — |
| Expiry date | Jul 26, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/6006
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are recombinant Listeria strains expressing a tumor-specific antigenic polypeptide and, optionally, an angiogenic polypeptide wherein a nucleic acid molecule encoding at least one of the polypeptides is operably integrated into the Listeria genome in an open reading frame with a nucleic acid sequence encoding a PEST-containing polypeptide, methods of preparing same, and methods of inducing an immune response, and treating, inhibiting, or suppressing cancer or tumors comprising administering same.
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