Methods of synthesizing γ-aapeptides, γ-aapeptide building blocks, γ-aapeptide libraries, and γ-aapeptide inhibitors of Aβ40 aggregates

US9645155B2 · kind B2 · utility

Assignee

• University of South Florida · US

Inventors

• Jianfeng Cai · Tampa, US
• Chuanhai Cao · Temple Terrace, US
• Haifan Wu · Tampa, US
• Yaqiong Li · Tampa, US
• Ge Bai · Tampa, US

Key dates

• Filing date: Aug 18, 2014
• Grant date: May 9, 2017
• Expiry date: Aug 18, 2034

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/2821
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments of the present disclosure provide for γ-AApeptides, γ-AApeptide building blocks, methods of making γ-AApeptides and libraries of γ-AApeptides, methods of screening the γ-AApeptide libraries for desired peptidomimetic activity, and the like. The present disclosure also provides for γ-AApeptides that are inhibitors of Aβ peptide aggregation, methods of inhibiting and disassembling Aβ peptide aggregation, methods of inhibiting the toxicity of Aβ aggregates towards N2a neuroblasotma cells, as well as methods and compounds for treating Alzheimer's disease.