Methods for use of neural stem cell compositions for treatment of central nervous system lesions

US9649358B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• DEPARTMENT OF VETERANS AFFAIRS · US

Inventors

• Paul P. Lu · San Diego, US
• Mark H. Tuszynski · Village of La Jolla, US

Key dates

• Filing date: Dec 10, 2012
• Grant date: May 16, 2017
• Expiry date: Dec 10, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods for inducing non-embryonic lesioned central nervous system neurons to survive, integrate, extend axons over long distances, induce intra-lesion ingrowth of neurons into the lesion from host tissue and form synapses in vivo. Pluripotent neural stem cells are grafted into the lesioned CNS tissue within a tissue adhesive suspension, optionally in the presence of growth factors. No modification of the neuronal regenerative inhibitory environment of the CNS is necessary.