Particles with multiple functionalized surface domains

US9649391B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• The Brigham and Women's Hospital, Inc. · US

Inventors

• Omid C. Farokhzad · Sharon, US
• Carolina Salvador-Morales · Brookline, US
• Weiwei Gao · Village of La Jolla, US
• Liangfang Zhang · San Diego, US
• Juliana M. Chan · Cambridge, US
• Robert S. Langer · Newton, US

Key dates

• Filing date: Apr 13, 2016
• Grant date: May 16, 2017
• Expiry date: Apr 13, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This disclosure relates to particles (e.g., nanoparticles and microparticles) that display multiple functionalized surface domains in a controlled mosaic pattern. The disclosure also provides simple methods to create various particles that have multiple functionalized surface domains while allowing the use of a wide variety of diverse core structures. The multiple functionalized domains provide controllable particle binding and orientation, and controlled and sustained drug release profiles.