Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy

US9650334B2 · kind B2 · utility

Assignees

• Abb Vie Inc. · US
• Abb Vie Deutschland Gmbh & Co. KG · DE

Inventors

• Wilhelm Amberg · Ludwigshafen, DE
• Frauke Pohlki · Wiesbaden, DE
• Udo Lange · Ludwigshafen, DE
• Ying Wang · Lake Villa, US
• Hongyu Zhao · Libertyville, US
• Huan-Qiu Li · Cambridge, US
• Jason T. Brewer · Zion, US
• Irini Zanze · Libertyville, US
• Justin D. Dietrich · Libertyville, US
• Anil Vasudevan · Union Grove, US
• Stevan W. Djuric · Libertyville, US
• Yanbin Lao · Libertyville, US
• Charles W. Hutchins · Libertyville, US

Key dates

• Filing date: Mar 17, 2014
• Grant date: May 16, 2017
• Expiry date: Mar 17, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to pyrrolidine derivatives of the formula (I),or a physiologically tolerated salt thereof.The invention relates to pharmaceutical compositions comprising such pyrrolidine derivatives, and the use of such pyrrolidine derivatives for therapeutic purposes. The pyrrolidine derivatives are GlyT1 inhibitors.