Imidazo(4,5-B) pyridin-2-yl amides as KV7 channel activators

US9650376B2 · kind B2 · utility

Assignee

• KNOPP BIOSCIENCES, LLC · US

Inventors

• Lynn Resnick · Sayreville, US
• George T. Topalov · Pittsburgh, US
• Steven A. Boyd · Longmont, US
• Justin K. Belardi · Pittsburgh, US
• Charles A. Flentge · Salem, US
• James S. Hale · Pittsburgh, US
• Scott Harried · Calabasas, US
• David A. Mareska · McMurray, US
• Kai Zhang · Wexford, US
• Charles R. Heap · West Sand Lake, US
• Mark Hadden · Albany, US
• Wenge Cui · Clifton Park, US
• Helene Decornez · Clifton Park, US
• Shuang Liu · Schenectady, US

Key dates

• Filing date: Mar 17, 2014
• Grant date: May 16, 2017
• Expiry date: Mar 17, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds represented by formula 1 can be potent and/or partially selective for the Kv7.2/7.3 heteromultimer. They may be useful in treating disorders related to seizures, pain, neurotransmitter release, etc.