Platinum (II) compound, preparation method therefor, and pharmaceutical composition and application thereof

US9650403B2 · kind B2 · utility

Assignees

• SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY · CN
• China State Institute of Pharmaceutical Industry · CN

Inventors

• Baoquan ZHU · Shanghai, CN
• Yongzhi SHU · Shanghai, CN
• Jun Lin · Fuzhou, CN
• Haifeng Hu · Shanghai, CN
• Quanhai Liu · Shanghai, CN
• Bin Zhou · Zhaoqing, CN

Key dates

• Filing date: Mar 19, 2014
• Grant date: May 16, 2017
• Expiry date: Mar 19, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are a platinum (II) compound, a preparation method therefor, and a pharmaceutical composition and an application thereof. The preparation method comprises the following steps: enabling dihydrate diammine platinum nitrate (4) to react with the carboxylate ligand derivative (5) in water, to produce a platinum (II) compound. Also provided are an application of the platinum (II) compound in preparation of an antitumor drug, and a pharmaceutical composition. The pharmaceutical composition contains an active component and a medicinal carrier, the active component containing the platinum (II) compound, and the mass percentage of the active component being 0.1%-95%. The platinum (II) compound of the present invention is well water-soluble, low toxic, easily prepared, and efficient in antitumor activity.