Comparative genomic hybridization array method for preimplantation genetic screening
US9652585B2 · kind B2 · utility
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23Claims
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Key dates
| Filing date | Mar 16, 2010 |
| Grant date | May 16, 2017 |
| Priority date | — |
| Expiry date | Aug 27, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B20/00
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
A method for determining the presence of a copy number imbalance in genomic DNA of a test sample is provided. The method can separately measure hybridization of a single test sample to a first hybridization array and hybridization of a plurality of reference samples to a plurality of other, respective test arrays. A determination of copy number can be based on the best fit reference array, relative to the test array. The best fit can be determined based on the closest or most similar signal-to-noise ratio of the measured signals.
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