Matrix for sustained, invariant and independent release of active compounds

US9655855B2 · kind B2 · utility

Assignee

• PURDUE PHARMA L.P. · US

Inventors

• Bianca BRÖGMANN · Ulm, DE
• Silke Mühlau · Hamburg, DE
• Christof Spitzley · Hadamar, DE

Key dates

• Filing date: Sep 17, 2014
• Grant date: May 23, 2017
• Expiry date: Sep 17, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns a storage stable pharmaceutical formulation comprising preferably two active compounds in a non-swellable diffusion matrix, whereby the compounds are released from the matrix in a sustained, invariant and, if several compounds are present, independent manner and the matrix is determined with respect to its substantial release characteristics by ethylcellulose and at least one fatty alcohol. The invention also concerns methods for producing such pharmaceutical formulations.