Polymorphs of CDDO ethyl ester and uses thereof

US9656951B2 · kind B2 · utility

Assignee

• Applied Pharmaceutical Science, Inc. · CN

Inventors

• Xiaohong Zhang · Beijing, CN
• Lu Song · Beijing, CN
• Wendong Sun · Beijing, CN
• Kaiyang Liu · Beijing, CN
• Chunlei Han · Beijing, CN

Key dates

• Filing date: Dec 6, 2012
• Grant date: May 23, 2017
• Expiry date: Dec 6, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to polymorphic forms of the compound of Formula I (i.e., ethyl 2-cyano-3,12-dioxoIeana-1,9(11)-dien-28-oate (CDDO ethyl ester)) and methods of using them for treating a variety of disease states such as cancer and condisitons associated with inflammation.