Method for synthesizing key intermediate of apixaban
US9656958B2 · kind B2 · utility
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Key dates
| Filing date | Jul 29, 2014 |
| Grant date | May 23, 2017 |
| Priority date | — |
| Expiry date | Jul 29, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/76
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a method for synthesizing an intermediate of Apixaban comprising reacting a compound of formula I with 5-chloro-valeryl chloride in the presence of inorganic base in an inert solvent to obtain a compound of formula II, with the reaction formula of (A), wherein R is selected from nitro group and the group (B). The method is mild in reaction condition, simple in operation, easy in purification, inexpensive in production cost, environmental-friendly, and suitable for industrial production.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.