Substituted pyridines as sodium channel blockers

US9656959B2 · kind B2 · utility

Assignee

• PURDUE PHARMA L.P. · US

Inventors

• Chiyou Ni · Montgomery, US
• Minnie Park · Princeton Junction, US
• Bin Shao · Shanghai, CN
• Laykea Tafesse · Robinsville, US
• Jiangchao Yao · Princeton, US
• Mark A. Youngman · Warminster, US
• Xiaoming Zhou · Plainsboro, US

Key dates

• Filing date: Dec 21, 2011
• Grant date: May 23, 2017
• Expiry date: May 4, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to substituted pyridine compounds of Formula I: (I) and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein R1a, R1b, R2a, R2b, R2c, A1, A2, and X are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.