Intermediates for preparing triazole agonists of the APJ receptor

US9656998B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Ning Chen · Thousand Oaks, US
• Xiaoqi Chen · Palo Alto, US
• Richard V. Connors · Mesa, US
• Jeffrey Deignan · San Francisco, US
• Paul John Dransfield · Arlington, US
• Xiaohui Du · Foster City, US
• Zice Fu · Foster City, US
• Julie Anne Heath · Chico, US
• Daniel B. Horne · Natick, US
• Jonathan Houze · Cambridge, US
• Matthew R. Kaller · Ventura, US
• David John Kopecky · West Hollywood, US
• Su-Jen Lai · Somerville, US
• Zhihua Ma · Lexington, US
• Lawrence R. McGee · Pacifica, US
• Julio C. Medina · Redwood City, US
• Jeffrey T. Mihalic · San Francisco, US
• Nobuko Nishimura · Calabasas, US
• Steven H. Olson · Millbrae, US
• Vatee Pattaropong · Bedford, US
• Xiaodong Wang · Zhejiang, CN
• Kevin Yang · San Gabriel, US
• Mikkel V. Debenedetto · Shrewsbury, US
• Robert P. Farrell · Thousand Oaks, US
• Simon J. Hedley · Thousand Oaks, US
• Ted Judd · San Fernando, US

Key dates

• Filing date: Oct 20, 2016
• Grant date: May 23, 2017
• Expiry date: Oct 20, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formula V, salts thereof, tautomers thereof, and salts of the tautomers are useful intermediates in the synthesis of agonists of the APJ Receptor. Compounds of Formula V have the following structure:where the definitions of the variables are provided herein.