Compounds and uses

US9657001B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Robert Rönn · Uppsala, SE
• Carl Jonas Lindh · Uppsala, SE
• Erik Ringberg · Uppsala, SE
• Hanna Birgitta Ellinor Andersson · Göteborg, SE
• Peter Nilsson · Stuvsta-Snättringe, SE
• Wesley Schaal · Uppsala, SE
• Magnus Munck Af Rosenschöld · Mölndal, SE
• Antonios Nikitidis · Lund, SE
• Grigorios Nikitidis · Lund, SE
• Petra Johannesson · Mölndal, SE
• Christian Tyrchan · Mölndal, SE

Key dates

• Filing date: May 4, 2016
• Grant date: May 23, 2017
• Expiry date: May 4, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There is provided compounds of formula I,wherein E1, E2, E3, E4, L1, Y1, Y2, Y3, Ra and z have meanings provided in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of respiratory diseases and inflammation.