Ergoline compounds and uses thereof

US9657020B2 · kind B2 · utility

Assignee

• Xoc Pharmaceuticals · US

Inventors

• Thomas A. Armer · Cupertino, US
• Geoff McKinley · Mountain View, US
• Scott Borland · Los Gatos, US
• Miguel Guzman · Cupertino, US
• Ármin Szabolcs · Szombathely, HU
• János Gerencser · Budapest, HU

Key dates

• Filing date: Jan 20, 2016
• Grant date: May 23, 2017
• Expiry date: Jan 20, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are ergoline compounds and pharmaceutical compositions thereof. In some embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1A, 5-HT1B and 5-HT1D receptors without agonizing the 5-HT2B receptor using the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing the 5-HT2B adrenergic alpha2A and/or the alpha2B receptors using the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing the D2 and D3 receptor using the compounds and pharmaceutical compositions disclosed herein.