Patent · US Active

Antibodies specific for sclerostin and methods for increasing bone mineralization

US9657095B2 · kind B2 · utility

0Cited by

62References

22Claims

0Family size

Assignee

UCB PHARMA S.A. · BE

Inventors

David G. Winkler · Arlington, US
Jiye Shi · Slough, GB
John Latham · Seattle, US

Key dates

Filing date	Mar 19, 2015
Grant date	May 23, 2017
Priority date	—
Expiry date	Mar 20, 2035

Classification

Technology area (CPC G)Physics
CPC primaryG01N2333/4704
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.