Sequencing methods for prenatal diagnoses
US9657342B2 · kind B2 · utility
10Cited by
17References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 1, 2010 |
| Grant date | May 23, 2017 |
| Priority date | — |
| Expiry date | Jan 13, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/112
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides methods for determining aneuploidy and/or fetal fraction in maternal samples comprising fetal and maternal cfDNA by massively parallel sequencing. The method comprises a novel protocol for preparing sequencing libraries that unexpectedly improves the quality of library DNA while expediting the process of analysis of samples for prenatal diagnoses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.