Method of screening compounds for the treatment of diabetes
US9657348B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jan 13, 2014 |
| Grant date | May 23, 2017 |
| Priority date | — |
| Expiry date | Jan 13, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/042
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of screening for a candidate compound for the treatment of a condition involving dysregulation of metabolism in a mammal, by bringing a compound into contact with cells that express a GPCR and that further express a GRK, determining whether the contacting causes a response of the GRK in cells brought into contact with the compound, determining whether the contacting causes a response of a classical secondary messenger in cells brought into contact with the compound; and identifying the candidate compound based on the determined GRK response and response of a classical secondary messenger in the cells. A kit for use in the method. A compound for use in the treatment of a condition involving dysregulation of metabolism in a mammal and a method of treatment of such a condition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.