Patent · US Active

Compositions and methods to inactivate and/or reduce production of microbial toxins

US9662372B2 · kind B2 · utility

1Cited by
1References
10Claims
0Family size

Assignee

Inventors

Key dates

Filing dateFeb 20, 2014
Grant dateMay 30, 2017
Priority date—
Expiry dateFeb 20, 2034

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61P31/04
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

The present invention is related to compositions and methods to treat, ameliorate and/or prevent morbidity and/or mortality from microbial infections. In particular, bacterial infections that are associated with the production and release of bacterial toxins. For example, many Clostridia bacteria, such as Clostridium difficile, release toxins resulting in tissue and organ damage and death, even after antibiotic therapy that either reduces or eliminates the bacteria. In particular, various peptides, polypeptides, and proteins are disclosed herein that either inactivate Clostridium difficile toxin and/or reduce Clostridium difficile toxin production.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.