Composite tissue-engineered intervertebral disc with self-assembled annular alignment
US9662420B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 12, 2015 |
| Grant date | May 30, 2017 |
| Priority date | — |
| Expiry date | May 12, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2430/38
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.