Substituted triazolopyridines and their use as TTK inhibitors

US9663510B2 · kind B2 · utility

Assignees

• Bayer Pharma Aktiengesellschaft · DE
• Bayer Intellectual Property GmbH · DE

Inventors

• Volker Schulze · Hohen Neuendorf, DE
• Dirk Kosemund · Berlin, DE
• Antje Margret Wengner · Berlin, DE
• Gerhard Siemeister · Berlin, DE
• Detlef STÖCKIGT · Potsdam, DE
• Michael Brüning

Key dates

• Filing date: Dec 10, 2012
• Grant date: May 30, 2017
• Expiry date: Dec 10, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to substituted triazolopyridine compounds of general formula (I):in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.