Mutated immunoglobulin-binding polypeptides
US9663558B2 · kind B2 · utility
3Cited by
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17Claims
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Assignee
Inventors
Key dates
| Filing date | Jul 10, 2014 |
| Grant date | May 30, 2017 |
| Priority date | — |
| Expiry date | Jul 10, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/00
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A, as specified by SEQ ID NO 1 or SEQ ID NO 2, or of Protein Z, as specified by SEQ ID NO 3, wherein at least the glutamine residue at position 15 has been mutated to an amino acid other than asparagine. The invention also discloses multimers of the polypeptide, as well as separation matrices comprising the multimers or polypeptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.