Antibodies that bind peptidoglycan recognition protein 1

US9663568B2 · kind B2 · utility

Assignee

• Novo Nordisk A/S · DK

Inventors

• Vibeke Westphal Stennicke · Kokkedal, DK
• Christine Brender Read · Struer, DK
• Joseph L. Kuijper · Kenmore, US
• Xiaoting Tang · Lansdale, US
• Mark Heipel · Avenue Madeleine, DK
• Siv Annegrethe Hjorth · Avenue Madeleine, DK

Key dates

• Filing date: Nov 30, 2012
• Grant date: May 30, 2017
• Expiry date: Apr 12, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/76
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein is a method for identifying TREM-1's ligand and antibodies, or fragments thereof, which are capable of modifying the function of TREM-1's ligand. Antibodies that reduce or block TREM-1 activation may be identified and selected using this method. Antibodies that bind to TREM-1's ligand and reduce TREM-1 activity may be suitable for use as medicaments.