Engineered biocatalysts useful for carbapenem synthesis
US9663771B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Nov 28, 2016 |
| Grant date | May 30, 2017 |
| Priority date | — |
| Expiry date | Nov 28, 2036 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/52
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present disclosure provides engineered pNB esterase polypeptides useful for the synthesis of the carbapenem antibiotic, imipenem. The disclosure also provides polynucleotides encoding the engineered pNB esterases, host cells capable of expressing the engineered pNB esterases, and methods of using the engineered pNB esterases in the production of imipenem.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.