Patent · US Active

Methods and compositions for producing double allele knock outs

US9663782B2 · kind B2 · utility

24Cited by
7References
18Claims
0Family size

Assignee

Inventors

Key dates

Filing dateJul 19, 2014
Grant dateMay 30, 2017
Priority date—
Expiry dateFeb 14, 2035

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12Y302/01018
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

The present invention provides a method and compositions utilizing the CRISPR system to disrupt a target gene in eukaryotic cells to produce double allele knock outs. The method finds use in producing afucosylated antibodies with enhanced ADCC activity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.