RNA sequences that induce fluorescence of small molecule fluorophores
US9664676B2 · kind B2 · utility
4Cited by
3References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 8, 2014 |
| Grant date | May 30, 2017 |
| Priority date | — |
| Expiry date | Sep 8, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/10
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to novel nucleic acid molecules, called aptamers, that bind specifically to a small molecule fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.