Profiling of signal pathway proteins to determine therapeutic efficacy
US9664683B2 · kind B2 · utility
3Cited by
32References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 28, 2014 |
| Grant date | May 30, 2017 |
| Priority date | — |
| Expiry date | Feb 28, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/9121
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides methods for detecting, measuring and quantitating the activation states of components of the PI3K signaling pathway in cells such as tumor cells. In particular embodiments, the present invention enable the determination of tumor adaptation to anticancer therapy. Accordingly, the present invention provides methods for improved cancer therapy selection/adjustment and disease monitoring.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.