Patent · US Active

Immunogenic composition comprising elements of C. difficile CDTb and/or CDTa proteins

US9669083B2 · kind B2 · utility

3Cited by

0References

14Claims

0Family size

Assignee

GLAXOSMITHKLINE BIOLOGICALS SA · BE

Inventor

Cindy Castado · Rixensart, BE

Key dates

Filing date	Dec 20, 2013
Grant date	Jun 6, 2017
Priority date	—
Expiry date	Dec 20, 2033

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K2039/6068
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to immunogenic compositions comprising isolated Clostridium difficile CDTb and/or CDTa protein. In particular the isolated Clostridium difficile CDTb protein is suitably a truncated CDTb protein comprising the receptor binding domain or a mutated CDTb protein incapable of binding to CDTa, and the isolated Clostridium difficile CDTa protein is suitably a truncated CDTa protein which does not comprise the C-terminal domain. In particular the invention also relates to fusion proteins comprising a CDTa protein and a CDTb protein and also fusion proteins between an isolated Clostridium difficile toxin A protein and/or an isolated Clostridium difficile toxin B protein fused to a CDTb protein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.