Methods for making 3-O-protected morphinones and 3-O-protected morphinone dienol carboxylates
US9670218B2 · kind B2 · utility
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24Claims
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Key dates
| Filing date | Mar 3, 2015 |
| Grant date | Jun 6, 2017 |
| Priority date | — |
| Expiry date | Mar 3, 2035 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are methods for making aldehydes and ketones comprising allowing the corresponding primary or secondary alcohol to react in the presence of trichoroisocyanuric acid, a compound of formula R1SR2 and a base. In one embodiment, the alcohol is a compound of formula (I):wherein R3 is a protecting group.Also disclosed are methods for making 3-O-protected morphine dienol carboxylates comprising allowing a compound of formula (I) to oxidize in the presence of a chlorine-containing compound and a compound of formula R1SR2; and allowing the product of the oxidation step to react with an acylating agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.