IL-1 binding proteins

US9670276B2 · kind B2 · utility

Assignee

• Abb Vie Inc. · US

Inventors

• Susan E. Lacy · Shrewsbury, US
• Lorenzo Benatuil · Northborough, US
• Meha Chhaya · Shrewsbury, US
• Emma Fung · Northborough, US
• Renee Miller · Thompson, US
• Ravi Chari · Norwich, US
• Sarah J. Heighton · Leominster, US
• Jacqueline Bixby · Auburn, US

Key dates

• Filing date: Jul 12, 2013
• Grant date: Jun 6, 2017
• Expiry date: Sep 8, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure provides binding proteins that specifically bind to IL-1α and IL-1β. These binding proteins can be organized into DVD-Igs. These proteins can be used to modulate the activity of IL-1α and/or IL-1β and can be used for the treatment immunological diseases such as rheumatoid arthritis, osteoarthritis, psoriasis, multiple sclerosis, and other autoimmune diseases. In addition, their uses in the amelioration and/or treatment of pain in an individual suffering from a disease or disorder associated with IL-1 accumulation.