Tissue engineered constructs
US9670443B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jun 25, 2014 |
| Grant date | Jun 6, 2017 |
| Priority date | — |
| Expiry date | Jun 25, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2430/24
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of forming an implantable tissue engineered construct, a bioreactor for forming a tissue engineered construct, and a tissue engineered construct itself are disclosed The method includes seeding a scaffold with cells to form a tissue construct; locating the tissue construct in a space defined by a tissue construct support element; locating the tissue construct support element within a bioreactor; and operating a load applicator of the bioreactor to apply a cyclical compressive mechanical load to the tissue construct, to stimulate the deposition of tissue matrix in the tissue construct, in which the tissue construct, the tissue construct support element and the load applicator are arranged so that the load applicator can at least initially contact both the tissue construct and the tissue construct support element, so that at least part of a total load generated by the load applicator is borne by the tissue construct support element.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.