Patent · US Active

Use of stabilized granules containing glyceryl trinitrate for arteriogenesis

US9675552B2 · kind B2 · utility

1Cited by

15References

13Claims

0Family size

Assignee

DESMOID AKTIENGESELLSCHAFT · DE

Inventor

Michaela Gorath · Hamburg, DE

Key dates

Filing date	Dec 15, 2015
Grant date	Jun 13, 2017
Priority date	—
Expiry date	Dec 15, 2035

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K31/616
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention inter alia relates to a method of treating or preventing an arterial insufficiency, where an NO donor is administered in an intermitting manner to a subject in an amount of effective for the induction of arteriogenesis, and wherein the NO donor is a solid pharmaceutical preparation with the active substance glyceryl trinitrate for oromucosal or oral administration characterized in that it contains between 0.05 and 2 weight % glyceryl trinitrate (GTN), at least one diluent, one carrier material, and at least one substance that reduces the volatility of GTN, whereby this substance is a non-volatile ester stabilizer whose melting point is not higher than 60° C.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.