Methods for purifying trans-(−)-Δ9-tetrahydrocannabinol and trans- (+)-Δ9-tetrahydrocannabinol

US9675581B2 · kind B2 · utility

Assignee

• SVC Pharma LP · US

Inventors

• Arie Gutman · Haifa, IL
• Marina Etinger · Nesher, IL
• Irina Fedotev · Haifa, IL
• Ram Khanolkar · West Greenwich, US
• Gennady Nisnevich · Haifa, IL
• Boris Pertsikov · Nesher, IL
• Igor Rukhman · Nesher, IL
• Boris Tishin · Haifa, IL

Key dates

• Filing date: Mar 4, 2016
• Grant date: Jun 13, 2017
• Expiry date: Mar 4, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D311/80
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods for making trans-(−)-Δ9-tetrahydrocannabinol and trans-(+)-Δ9-tetrahydrocannabinol are disclosed herein. In one embodiment, a trans-(−)-Δ9-tetrahydrocannabinol composition is prepared by allowing a composition comprising (±)-Δ9-tetrahydrocannabinol to separate on a chiral stationary phase to provide a trans-(−)-Δ9-tetrahydrocannabinol composition comprising at least about 99% by weight of trans-(−)-Δ9-tetrahydrocannabinol based on the total amount of trans-(−)-Δ9-tetrahydrocannabinol and trans-(+)-Δ9-tetrahydrocannabinol. The invention also relates to methods for treating or preventing a condition such as pain comprising administering to a patient in need thereof an effective amount of a trans-(−)-Δ9-tetrahydrocannabinol having a purity of at least about 98% based on the total weight of cannabinoids.