Method of preparing bone material having enhanced osteoinductivity
US9675645B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jan 22, 2013 |
| Grant date | Jun 13, 2017 |
| Priority date | — |
| Expiry date | Mar 15, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2430/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for increasing osteoinductivity and/or surface area of bone material are provided. The methods include providing bone material and dehydrating the bone material with a solvent at its critical point. A useful solvent for critical point dehydrating is carbon dioxide. Critical point dehydration resulting in increased osteoinductivity and/or surface area can be applied to many types of bone material including bone particles, bone chips, bone fibers, bone matrices, both demineralized and non-demineralized. An implantable composition having an enhanced osteoinductivity and/or osteoconductivity is also provided. The implantable composition contains demineralized bone matrix dried at critical point of carbon dioxide. Critical point dried fibers of a demineralized bone matrix have a BET value from about 40 m2/gm to about 100 m2/gm, a value that is 100 times higher than corresponding vacuum dried or lyophilized DBM fibers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.