BET bromodomain inhibitors and therapeutic methods using the same

US9675697B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Shaomeng Wang · Saline, US
• Xu Ran · Ann Arbor, US
• Yujun Zhao · Ann Arbor, US
• Chao-Yie Yang · Hangzhou City, CN
• Liu Liu · San Diego, US
• Longchuan Bai · Ann Arbor, US
• Donna McEachern · Ann Arbor, US
• Jeanne Stuckey · Fenton, US
• Jennifer Lynn Meagher · Ann Arbor, US
• Duxin Sun · Ann Arbor, US
• Xiaoqin Li · Ann Arbor, US
• Bing Zhou · Ann Arbor, US
• Hacer Karatas · Ann Arbor, US
• Ruijuan Luo · Ann Arbor, US
• Arul M. Chinnaiyan · Plymouth, US
• Irfan A. Asangani · Ann Arbor, US

Key dates

• Filing date: Mar 11, 2014
• Grant date: Jun 13, 2017
• Expiry date: Mar 11, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/056
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Inhibitors of BET bromodomains and compositions containing the same are disclosed. Methods of using the BET bromodomain inhibitors in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, also are disclosed.