Aza-epoxy-guaiane derivatives and treatment of cancer

US9676788B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Health and Human Services · US
• UNIVERSITY OF HAWAII · US

Inventors

• William Chain · Newark, US
• John A. Beutler · Braddock, US
• David Fash · Honolulu, US
• William D. Figg · Fairfax, US
• Zhenwu Li · Wilmington, US
• Cody J. PEER · Frederick, US
• Joe William Ramos · Honolulu, US
• Florian Sulzmaier · San Diego, US

Key dates

• Filing date: Feb 5, 2015
• Grant date: Jun 13, 2017
• Expiry date: Feb 5, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a compound of formula (I) or formula (II): (Formulas should be inserted here) wherein R1-R6 are as defined herein. Also disclosed are a pharmaceutical composition comprising such a compound and a method of treating or preventing cancer in a mammal in need thereof, comprising administering to the mammal a compound of formula (I) or formula (II).