Multiphase systems for diagnosis of sickle cell disease

US9678088B2 · kind B2 · utility

Assignees

• President and Fellows of Harvard College · US
• Children's Medical Center Corporation · US
• The Brigham and Women's Hospital, Inc. · US

Inventors

• George M. Whitesides · Newton, US
• Ashok Kumar · Malden, US
• Jonathan W. Hennek · Somerville, US
• Caeul Lim · Boston, US
• Yovany Moreno · Alpharetta, US
• Charles R. Mace · Watertown, US
• Manoj T. Duraisingh · Cambridge, US
• Matthew R. Patton · Cambridge, US
• Si-yi Ryan Lee · Cambridge, US
• Gaetana D'Alesio-Spina · Cambridge, US
• Carlo Brugnara · Newton, US
• Thomas P. Stossel · Belmont, US

Key dates

• Filing date: Apr 28, 2014
• Grant date: Jun 13, 2017
• Expiry date: Apr 28, 2034

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/22
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

An aqueous multi-phase system for diagnosis of sickle cell disease is described, including two or more phase-separated phases including: a first aqueous phase including a first phase component and having a first density between about 1.025 g/cm3 and about 1.095 g/cm3; and a second aqueous phase including a second phase component and having a second density between about 1.100 g/cm3 and about 1.140 g/cm3; wherein the first density is lower than the second density; and each of the first and second phase components include at least one polymer.