Patent · US Active

Mammal with an orthotopic tumor capable of metastasis, a method of making and a method of using

US9681647B2 · kind B2 · utility

0Cited by

3References

3Claims

0Family size

Assignee

Cornell University · IT

Inventors

Huanhuan Chen · Great Neck, US
Steven M. Lipkin · Scarsdale, US
Xiling Shen · Chapel Hill, US

Key dates

Filing date	Jul 3, 2013
Grant date	Jun 20, 2017
Priority date	—
Expiry date	Jul 30, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2830/003
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided are compositions and methods that involve cancer cells which are modified so that they can form orthotopic tumors in a non-human mammal, and wherein metastasis of the tumor can be controlled. The cancer cells, which may be human cancer cells, are modified so that expression of a human chemokine receptor can be modulated. Modulating expression of the human chemokine receptor allows selective initiation of metastasis. Kits which contain the modified cancer cells are provided. A method for identifying agents which can inhibit metastasis using non-human mammals having orthotopic tumors formed using the modified cancer cells is also included.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.