Amide compounds, compositions and applications thereof

US9682953B2 · kind B2 · utility

Assignee

• Advinus Therapeutics Limited

Inventors

• Rajendra Kharul · Ahmedabad, IN
• Debnath Bhuniya · Pune, IN
• Kasim Mookhtiar · Jamkhed, IN
• Umesh Singh · Pune, IN
• Atul Hazare · Pune, IN
• Satish Prakash Patil · Windom, US
• Laxmikant Datrange · Pune, IN
• Mahesh Thakkar · Pune, IN

Key dates

• Filing date: Sep 21, 2012
• Grant date: Jun 20, 2017
• Expiry date: Sep 23, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65616
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to substituted amide compounds that are inhibitors of Fatty Acid Amide Hydrolase (FAAH), their stereoisomers, tautomers, prodrugs, polymorphs, solvates, pharmaceutically acceptable salts, and pharmaceutical compositions containing them. These compounds are useful in the treatment, prevention, prophylaxis, management, or adjunct treatment of all medical conditions related to inhibition of Fatty Acid Amide Hydrolase (FAAH), such as pain including acute and post operative pain, chronic pain, cancer pain, cancer chemotherapy induced pain, neuropathic pain, nociceptive pain, inflammatory pain, back pain, pain due to disease of various origin such as: diabetic neuropathy, neurotropic viral disease including human immunodeficient virus (HIV), herpes zoster such as post herpetic neuralgia; polyneuropathy, neurotoxicity, mechanical nerve injury, carpal tunnel syndrome, immunologic mechanisms like multiple sclerosis; sleep disorders, anxiety and depression disorders, inflammatory disorders, weight and eating disorders, Parkinson's disease, addiction, spasticity, hypertension or other disorders. The disclosure also relates to the process of preparation of the am…