BMP inhibitors and methods of use thereof

US9682983B2 · kind B2 · utility

Assignees

• The Brigham and Women's Hospital, Inc. · US
• Dept. of Health and Human Services, National Institutes of Health · US

Inventors

• Asaf Alimardanov · Nanuet, US
• Gregory D. Cuny · Houston, US
• Gurmit Grewal · Natick, US
• Arthur Lee · San Jose, US
• John C. McKew · Ames, US
• Agustin H. Mohedas · Somerville, US
• Min-Jui Richard Shen · Boyds, US
• Xin Xu · Dongying, CN
• Paul B. Yu · Boston, US

Key dates

• Filing date: Mar 13, 2014
• Grant date: Jun 20, 2017
• Expiry date: Mar 13, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.