Methods for the preparation of alcaftadine

US9682984B2 · kind B2 · utility

Assignee

• CRYSTAL PHARMA, S.A.U. · ES

Inventors

• Antonio Lorente Bonde-Larsen · Valladolid, ES
• Jesús Miguel Iglesias Retuerto · Boecillo, ES
• Franciso Javiér Gallo Nieto · Boecillo, ES
• Juan José Ferreiro Gil · Boecillo, ES

Key dates

• Filing date: Mar 24, 2014
• Grant date: Jun 20, 2017
• Expiry date: Mar 24, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to new and improved processes for the preparation of Alcaftadine and pharmaceutically acceptable salts thereof as well as an intermediate for the preparation of Alcaftadine. The new process saves a number of steps compared to the known process and results in a higher yield.