Patent · US Active

PD-1 specific antibodies and uses thereof

US9683043B2 · kind B2 · utility

4Cited by
2References
14Claims
0Family size

Assignee

Inventors

Key dates

Filing dateJan 2, 2015
Grant dateJun 20, 2017
Priority date—
Expiry dateJan 8, 2035

Classification

  • Technology area (CPC G)Physics
  • CPC primaryG01N2333/70503
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

One aspect of the present disclosure provides antibodies that can act as agonists of PD-1, thereby modulating immune responses regulated by PD-1. Another aspect of the disclosure provides compositions comprising PD-1 specific antibodies and their use in methods of down regulating the immune response. These methods can be practiced on any subject, including humans or animals. Anti-PD-1 antibodies disclosed herein may be used, in another aspect of the invention to detect PD-1 or its fragments in a biological sample. The amount of PD-1 detected may be correlated with the expression level of PD-1, and associated with the activation status of immune cells (e.g., activated T cells, B cells, and/or monocytes) in the subject.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.