Methoxypolyethylene glycol-polylactic acid block copolymer and preparation method thereof
US9683073B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Jul 16, 2014 |
| Grant date | Jun 20, 2017 |
| Priority date | — |
| Expiry date | Jul 16, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08L67/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A methoxypolyethylene glycol-polylactic acid block copolymer is disclosed, the methoxypolyethylene glycol-polylactic acid block copolymer being a block copolymer formed by ring opening polymerization of D,L-lactide and methoxypolyethylene glycol. A mass ratio of the methoxypolyethylene glycol to the D,L-lactide is 1:0.55-0.65 or 1:0.73-0.89 or 1:0.91-0.99. A preparation method of the foregoing block copolymer is also provided. When the block copolymer is used as a carrier for preparing a drug micelle, the encapsulation efficiency of the drug micelle prepared after being re-dissolved by water can be greater than 90% at 12 hours.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.