Artificial nucleic acid molecules for improved protein or peptide expression
US9683233B2 · kind B2 · utility
51Cited by
5References
22Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 27, 2013 |
| Grant date | Jun 20, 2017 |
| Priority date | — |
| Expiry date | Mar 27, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/105
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to an artificial nucleic acid molecule comprising at least one 5′UTR element which is derived from a TOP gene, at least one open reading frame, and preferably at least one histone stem-loop. Optionally the artificial nucleic acid molecule may further comprise, e.g. a poly(A)sequence, a poyladenylation signal, and/or a 3′UTR. The invention further relates to the use of such an artificial nucleic acid molecule in gene therapy and/or genetic vaccination.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.