Wound dressings for the controlled release of therapeutic agents
US9687581B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 6, 2014 |
| Grant date | Jun 27, 2017 |
| Priority date | — |
| Expiry date | Oct 6, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/604
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A wound dressing material for controlled activation of a wound healing therapeutic compound in the presence of a protease enzyme in a wound fluid, the material comprising: a medically acceptable polymer; a wound healing therapeutic agent; an inhibitor of the protease enzyme; and a linker group which is cleavable by the protease enzyme, wherein the activities of both the wound healing therapeutic agent and the inhibitor are increased by contacting the wound dressing material with a would fluid containing the protease enzyme. For example, the enzyme may be a matrix metalloproteinase, the therapeutic agent may be a reactive oxygen scavenger, and the inhibitor may be a tissue inhibitor of metalloproteinase (TIMP).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.