Deoxycytidine kinase binding compounds

US9688673B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Caius G. Radu · Los Angeles, US
• Hsiang-I Liao · Arcadia, US
• Nagichettiar Satyamurthy · Los Angeles, US
• Johannes Czernin · Santa Monica, US
• Jennifer M. Murphy · Los Angeles, US
• David A. Nathanson · Los Angeles, US

Key dates

• Filing date: Mar 8, 2012
• Grant date: Jun 27, 2017
• Expiry date: Dec 26, 2032

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/5088
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides compounds that bind to deoxycytidine kinase (dCK) and compositions including pharmaceutically acceptable compositions containing the compounds. The compounds are useful in treating diseases and disorders where dCK activity is implicated such as cancer and immune disorders. The compounds also find use in clinical methodologies including positron emission tomography (PET) imaging.