Macrocyclic quinazole derivatives and their use as MTKI

US9688691B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Eddy Jean Edgard Freyne · Rumst, BE
• Marc Willems · Beerse, BE
• Peter Ten Holte · Beerse, BE
• Alexandra Papanikos · Ekeren, BE
• Werner Constant Johan Embrechts · Beerse, BE
• Pierre-Henri Storck · Abingdon, GB
• Virginie Sophie Poncelet · Rodez, FR

Key dates

• Filing date: May 22, 2014
• Grant date: Jun 27, 2017
• Expiry date: Jun 24, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention concerns the compounds of formulathe N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein