Low acidic species compositions and methods for producing and using the same using displacement chromatography
US9688752B2 · kind B2 · utility
10Cited by
238References
28Claims
0Family size
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Key dates
| Filing date | Mar 2, 2015 |
| Grant date | Jun 27, 2017 |
| Priority date | — |
| Expiry date | Mar 2, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/565
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods for producing such low AR compositions using displacement chromatography. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.